WebAnimal experiments with triethylene thiophosphoramide demonstrated its effectiveness in producing regression of Flexner—Jobling carcinoma on Sprague—Dawley rats and in the inhibition of the development of metastatic foci from rat mammary adenocarcinoma. N-N′-N″-TRIETHYLENE thiophosphoramide is a sulfur derivative of triethylene phosphoramide, … WebApr 15, 2011 · Celastrol, derived from the roots of the Tripterygium Wilfordi, has attracted interest for its potential anti-inflammatory and lipid-lowering activities.In the present study, the protective effect of celastrol on carbon tetrachloride (CCl 4)-induced acute liver injury was investigated.Celastrol improved the increased transaminase activity, inflammation, …
Quantification of N, N’ N’’-triethylenethiophosphoramide, N, N’ N ...
WebMetabolism: Rapidly and extensively metabolised in the liver via oxidative desulfuration by CYP2B6 and CYP3A4 isoenzymes to the major and active metabolite, triethylenephosphoramide (TEPA). Excretion: Via urine (<2% as unchanged drug, <11% as TEPA). Elimination half-life: 1.5-4.1 hours (thiotepa); 4.9-17.6 hours (TEPA). WebFeb 1, 1990 · Rat liver microsomes were found to catalyze conversion of thio-TEPA to its oxo metabolite, N,N′,N″-triethylenephosphoramide (TEPA), in a P-450-dependent reaction that was markedly stimulated by prior in vivo treatment with drug inducers of hepatic P-450 subfamily IIB (phenobarbital), but not by pretreatment with inducers of P-450 subfamilies … gooseberry chutney recipe
Influence of the tissue distribution of ThioTEPA and its metabolite ...
WebSimultaneous quantification of cyclophosphamide, 4-hydroxycyclophosphamide, N,N',N"-triethylenethiophosphoramide (thiotepa) and N,N',N"-triethylenephosphoramide (tepa) in … WebThiotepa (INN), sold under the brand name Tepadina, is a medication used to treat cancer.. Thiotepa is an organophosphorus compound with the formula (C 2 H 4 N) 3 PS. It is an analog of N,N′,N′′-triethylenephosphoramide (TEPA), which contains tetrahedral phosphorus and is structurally akin to phosphate.It is manufactured by heating aziridine with … WebBuy highly pure Triethylenephosphoramide, CAS No : 545-55-1, Mol.Formula : C6H12N3OP, Mol.Weight : 173.15, from Pharmaffiliates. Login as registered user for prices ... gooseberry chutney recipe uk