2024 Topbp1 cancer

Topbp1 cancer

Author: ltgg

August undefined, 2024

WebTOPBP1 is believed to allosterically activate ATR via its ATR activation domain (AAD), located between BRCT6 and BRCT7 ( 10, 11 ). Recently, Ewing tumor-associated antigen 1 (ETAA1), containing a motif with sequence similarity to AAD, was identified as a second ATR-activator protein ( 15 – 17 ). Web广西壮族自治区人民医院. 被引频次. 655. 成果数. 162. h指数. 14. g指数. 19.

TOPBP1 regulates RAD51 phosphorylation and chromatin loading …

Web28. feb 2007 · Aims: The TopBP1 protein includes eight BRCT domains (originally identified in BRCA1) and has homology with BRCA1 over the carboxyl terminal half of the protein. The aim of this study was to determine whether TopBP1 is aberrantly expressed in breast cancer. Methods and results: Sixty‐one breast carcinomas from an unselected … WebPatients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent. Read more. TOPBP1 is not prognostic in prostate cancer. avalon seven meadows katy tx

TOPBP1 DNA topoisomerase II binding protein 1 [ (human)]

TOPBP1 was first identified as a DNA damage protein through its association with BRCA1, which is a protein heavily implicated in breast cancer pathology. TOPBP1 was found in complex with BRCA1 at sites independent from replication forks (i.e identified by the DNA replication clamp proliferating cell nuclear antigen) during normal S phase. When DNA damage was induced at higher levels by γ irradiation, there was an increase in TOPBP1/BRCA1 at sites away from replicat… Web12. sep 2014 · The expression levels of TopBP1 and Claspin were increased in the cancer cells that survived radiation therapy. Depletion of TopBP1 or Claspin using shRNA showed … WebTOPBP1 PATHOLOGY CANCER ANTIBODIES AND VALIDATION Dictionary Human pathology PROGNOSTIC SUMMARYi Prognostic marker in liver cancer (unfavorable), endometrial cancer (unfavorable) and pancreatic cancer (unfavorable) avalon shipbroking

Disrupting PHF8-TOPBP1 connection elicits a breast tumor …

Topbp1 cancer

Overexpression of TopBP1 leads to transformation with a TP53

http://www.cancerindex.org/geneweb/TOPBP1.htm WebObjective: Topoisomerase IIβ binding protein 1 (TopBP1) is involved in DNA damage and replication checkpoint and has been shown to be related to tumorigenesis in many …

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Web20. máj 2024 · Here, we report that TOPBP1 interacts with the RNA-binding protein HTATSF1 in a cell-cycle- and phosphorylation-dependent manner. Mechanistically, CK2 phosphorylates HTATSF1 to facilitate binding to TOPBP1, which promotes S-phase-specific TOPBP1 recruitment to damaged chromatin and subsequent RPA/RAD51-dependent HR, genome … Web28. apr 2012 · TopBP1 possesses eight BRCA1 (breast cancer gene 1) carboxyl-terminal (BRCT) domains which were for the first time described for BRCA1 protein and are commonly found in proteins involved in regulation of the cell cycle checkpoint and the response of the cell to DNA damage [ 1, 3 – 5 ].

Web11. nov 2024 · We finally describe proof-of-concept experiments that support targeting CIP2A, or its interaction with topoisomerase 2-binding protein 1 (TOPBP1), as an … Webpred 15 minútami · Ovarian cancer has a specific unmet clinical need, with a persistently poor 5-year survival rate observed in women with advanced stage disease warranting continued efforts to develop new treatment options. The amplification of BRD4 in a significant subset of high-grade serous ovarian carcinomas (HGSC) has led to the …

Web28. apr 2012 · Aberrant expression of TopBP1 may lead to genomic instability and can have pathological consequences. In this study we aimed to investigate expression of TopBP1 … Web5. apr 2024 · TopBP1 to be upregulated in breast cancer tissues. TopBP1 overexpression was associated with higher-grade tumors and reduced patient survival (Forma et al., 2012; Going et al., 2007; Liu et al., 2009). p53 is a well-studied tumor suppressor and in the majority of cancers, p53 is mutated leading to gain of function mutations in the

Web1. feb 2016 · Topoisomerase IIβ-binding protein 1 (TOPBP1) participates in DNA replication and DNA damage response; however, its role in DNA repair and relevance for human …

Web25. jan 2016 · TOPBP1 is a large, nine BRCT domain–containing protein with essential roles in cellular processes, including DNA repair, replication, and transcription ( Sokka et al., 2010 ). TOPBP1 enhances ATR kinase activity ( Kumagai et al., 2006) through interaction with ATR partner protein ATRIP ( Mordes et al., 2008 ). avalon shutters nvWeb10. jan 2024 · Our studies show that TopBP1 expression is increased in cervical intraepithelial neoplasia and cervical squamous cell carcinoma as well as in HPV-positive cell lines in culture. Knockdown of... htl lamorbey term datesWeb15. mar 2024 · Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy 29 June 2024 Yan Zhao, Xinping Huang, … htl ball salzburg 2023 kartenWeb1. mar 2024 · Our finding that the TOPBP1/PARP1 pathway facilitates acquisition of oxaliplatin resistance uncovers a novel mechanism underlying platinum-based … avalon shopeeWeb12. sep 2014 · The expression levels of TopBP1 and Claspin were increased in the cancer cells that survived radiation therapy. Depletion of TopBP1 or Claspin using shRNA showed an enhancement of sensitivity to radiation in radioresistant lung cancer cells (PC14PE6). Moreover, increased levels of TopBP1 or Claspin endowed cells a higher resistance to … avalon salon san antonioWeb1. feb 2024 · However, the regulation of TopBP1 in DNA-damage responses remains unclear. In this study, we identify the deubiquitinating enzyme (DUB) USP13 as an important regulator of TopBP1. Mechanistically ... htl bateriasWeb31. aug 2024 · Here, we demonstrate that CIP2A is selectively essential for DNA damage-induced initiation of mouse BLBC tumors, but not of other cancer types. Mechanistically, … htl jenbach maturaball