Thiopental distribution
WebMost sedative-hypnotic drugs are lipid-soluble and are absorbed well from the gastrointestinal tract, with good distribution to the brain. Drugs with the highest lipid solubility (eg, thiopental) enter the CNS rapidly and can be used as induction agents in anesthesia.The CNS effects of thiopental are terminated by rapid redistribution of the … WebMain page; Contents; Current events; Random article; About Wikipedia; Contact us; Donate; Help; Learn to edit; Community portal; Recent changes; Upload file
Thiopental distribution
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WebDrug Distribution to Tissues. After a drug enters the systemic circulation, it is distributed to the body’s tissues. Distribution is generally uneven because of differences in blood … WebDexmedetomidine significantly decreased distribution volumes (V2, V3, and Vdss) and distribution clearances (Cl12 and Cl13) of thiopental. Conclusions: The thiopental dose …
WebThus, these studies suggest that the concentration of thiopental at induction varies between 10 and 100 micro gram *symbol* ml sup -1. Because about 75% of serum thiopental is bound to protein, the actual concentration of free drug at induction may range between approximately 2.5 and 25 micro gram *symbol* ml sup -1. WebApr 23, 2024 · The distribution and fate of Pentothal (thiopental sodium) (as with other barbiturates) is influenced chiefly by its lipid solubility (partition coefficient), protein …
WebThe pharmacokinetics of indocyanine green, a marker of the intravascular behavior of antipyrine and thiopental, and antipyrine in these dogs was nearly identical to that described previously in dogs anesthetized with 1.5% halothane but not given thiopental. The total volume of distribution of the highly lipophilic drug thiopental was more than ... WebMay 9, 2008 · The model also predicts a decrease in whole body distribution clearance with increasing residence time dispersion $${({\rm RD}_{\rm D}^2)}$$ . ... Weiss M, Krejcie TC, Avram MJ (2007) A minimal physiological model of thiopental distribution kinetics based on a multiple indicator approach. Drug Metab Disp 35: 1525–1532.
WebFeb 2, 2024 · Thiopental sodium Updated 2 Feb 2024 Barbiturates (in anaesthesia) Share Check interactions Drugs List Therapeutic Indications Dosage Administration Contraindications Precautions and Warnings Pregnancy and Lactation Side Effects Monograph Drugs List thiopental sodium 500mg powder for solution for injection
WebAbstract. Thiopental is an ultra short-acting barbiturate which remains the standard against which other induction agents are judged; it is also indicated for the therapy of brain … greece cruises september 2023WebJan 18, 2024 · Elimination rate and half-life of thiopental in the T1 group compared to the control and T2 groups showed a significant decrease and increase, respectively. In addition, the distribution of... greece currency to euroWebThiopental sodium and propofol dosages are calculated on total body weight (TBW). The loading dose of lipophilic opioids is based on TBW, whereas maintenance dosages should be cautiously reduced because of the higher sensitivity of the obese patient to their depressant effects. ... In the obese patient, the volume of distribution is increased ... florists in leven fifeWebThiopental sodium is a highly lipophilic agent. Following intravenous bolus dose of thiopental sodium, it rapidly distributes to the highly perfused organs such as brain, liver, … florists in lehigh valley paWebA mathematical pharmacokinetic model, including flow limitations, lipid solubility, protein binding, and metabolism, is used to make a priori predictions of the distribution of thiopental in four body regions. Tissue binding is correlated by means of “effective” protein fractions and bovine serum albumin data. florists in lewisburg tnWebSep 6, 2024 · Thiopental is a very rapid depressant that has distribution into the central nervous system within 30–45 seconds and, although it has no role in inducing analgesia, causes hypnosis and anesthesia. This feature has led to its widespread use in veterinary medicine to induce anesthesia in animals. greece current legal systemWebThiopental C11H18N2O2S CID 3000715 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ... florists in lewiston id