http://materiais.dbio.uevora.pt/BD/Diferenciacao/TGFb-induced_epithelial_to_mesenchymal_transition.pdf Webligands, the b catenin destruction complex, which is composed of adenomatous polyposis coli (APC), glycogen synthase kinase 3 (GSK3), and axin, is formed and leads to the …
Effects of miR-140-5p on Wnt1, β-catenin, collagen-I, TGF-β1, and …
Because of the crucial role of TGF-β in fibrotic disease, we speculated that TGF-β signalling might contribute to activation of the canonical Wnt pathway. Stimulation with TGF-β induced nuclear accumulation of β-catenin in cultured fibroblasts (Fig. 5a) and increased the activity of Tcf/Lef-responsive elements in … See more To investigate the activation of the canonical Wnt cascade, we first assessed the nuclear accumulation of β-catenin in human fibrotic tissue. Skin sections derived from patients … See more To investigate the functional role of the canonical Wnt pathway in fibrosis, human dermal fibroblasts were incubated with Wnt-1, which we found upregulated in human fibrotic diseases. Wnt-1 stimulated the transcriptional … See more To determine whether the downregulation of Dkk-1 is required for the profibrotic effects of TGF-β, we evaluated the extent of fibrosis in Dkk-1 tg mice infected with Ad-TBRIact. Overexpression of TBRIact in the skin induced … See more We next investigated whether inhibition of the canonical Wnt pathway blocks the development of fibrosis. Overexpression of the endogenous inhibitor Dkk-1 was chosen to target the canonical Wnt pathway, because Dkk … See more dc 1099 filing
TGF-β modulates β-Catenin stability and signaling in …
Webproapoptotic role in the liver, TGF-b is considered to function as a tumor suppressor (Rossmanith and Schulte-Hermann, 2001). On the contrary, TGF-b provides tumor … Web1 Mar 2006 · For instance, TGF-β mediated repression of E-cadherin with loss of E-cadherin expression results in the translocation of β-catenin from cell–cell contacts to the cytoplasm and the induction of ... WebNational Center for Biotechnology Information dc-10 cockpit image