Gspt1 off target
WebAug 20, 2024 · GSPT1 (G1 to S phase transition 1) is a translation termination factor that recognizes the termination codon by binding eRF1, forcing the proteins to dissociate from the ribosome after... WebApr 9, 2024 · miR-144 was found to be down-regulated in gastric cancer tissues while GSPT1 expression level was markedly increased; GSPT1 was a direct target of miR-144. PABP enhances the productive binding of the eRF1-eRF3 complex to the ribosome, via interactions with the N-terminal domain of eRF3a which itself has an active role in …
Gspt1 off target
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WebMar 2, 2024 · G1 to S phase transition protein 1 homologue (GSPT1; also known as eRF3a) is a target of thalidomide analogues CC-885 and the … WebDec 1, 2024 · Translation termination factor GSPT1 is a phenotypically relevant off-target of heterobifunctional phthalimide degraders. ACS Chem Biol, 13 (3) (2024), pp. 553-560. …
WebThe signal from a luciferase reporter was significantly decreased at one miR-133α target site at the 3'UTR of GSTP1, suggesting that miR-133α directly regulates GSTP1. Our … WebCC-90009, which selectively degrades the new target GSPT1, demonstrated its activity in the treatment of acute myeloid leukemia [30]. This is a new indication for ImiD-type drugs. In this clinical trial, ... TPD causes complete POI or off-target protein degradation, ...
WebMar 15, 2024 · In cancer cells, one of the genes is inactivated by a mutation; the other will be switched off by a drug. Known as molecular glues, Monte Rosa’s treatments are small molecules designed to treat disease by commandeering the body’s own protein-degrading processes. ... GSPT1, the target of Monte Rosa’s lead program, isn’t druggable by more ... WebJun 28, 2024 · The recent discovery of thalidomide analogs that degrade G 1 to S phase transition 1 (GSPT1) via the CRL4 CRBN ubiquitin ligase highlighted GSPT1 as a novel …
WebThese antibodies target GSPT1 in Human, Mouse and Rat samples. Our GSPT1 polyclonal antibodies are developed in Rabbit. These antibodies have been verified by Knockdown …
WebApr 1, 2024 · However, it is going to be critical to monitor off-target activities in the discovery and development of both new CELMoDs and cereblon dependent … perimeter institute for clinical researchWebMar 28, 2024 · GSPT1 is a protein involved in the termination of translation, SALL4 is a transcription factor often over-expressed in HCC patients and correlating with poor prognosis, and NEK7 is a protein in... perimeter inst theoret physperimeter institute of theoretical physicsWebSep 16, 2024 · Ishoey, M. et al. Translation termination factor GSPT1 is a phenotypically relevant off-target of heterobifunctional phthalimide degraders. ACS Chem. Biol. 13 , 553–560 (2024). Article CAS ... perimeter institute online courseWebNov 13, 2024 · Background: CC-90009 is a cereblon (CRBN) E3 ligase modulator (CELMoD) and a first-in-class small molecule that drives the binding of a novel target protein, G1 to S phase transition 1 (GSPT1), to CRBN, resulting in the proteasome-dependent degradation of GSPT1. GSPT1 plays a central role in mRNA translation, and … perimeter insulation for screedWebCEREP (panel with 44 proteins) tested at 10 µM No off target MRT-2359, a Rationally Designed GSPT1 MGD MRT-2359 is a Selective Inducer of Cereblon Proximity and GSPT1 MGD Representative Viability Curves in NSCLC Lines Real-world molecular and genomic data analyses performed on 3241 lung cancers (in collaboration with Tempus, Inc.) perimeter insulationWebJan 22, 2024 · GSPT1 is a common CRBN neosubstrate and degradation is induced by CELMoDs, like CC-885 [25], BTX306 [40], or CC-90009 [29], or as an off-target in the … perimeter insulation board