WebG-quadruplex-forming sequences are also enriched in the 5′ untranslated regions of many genes, ... In our approach, atomic-level models are built using folding principles gleaned … WebDec 21, 2010 · G-quadruplexes are a family of nucleic acid secondary structures based on the formation and stacking of quartets of coplanar guanines (G-quartets) ( Figure 1 ); they are stabilized by several cations, in particular potassium and sodium ( 37 ).
Quadruplex Folding Promotes the Condensation of Linker …
WebNov 7, 2024 · The term G-quadruplex encompasses a variety of conformations differing by their number of G-quartets, loop length and geometry, relative orientation of the G-tract strands, molecularity, and other non-canonical features (e.g. mixed quartets, extended quartets such as hexads or heptads, and additional features including triplets, base pairs … WebJul 1, 2024 · The precise suite of mechanisms by which biological systems modulate this equilibrium is not fully characterized. Several nucleic acid-binding proteins are known to alter G quadruplex folding, including ATP-dependent helicases [23], as well as non-helicase proteins, such as Lin28 and nucleolin, that do so in an energy-independent fashion [24, 25]. shanice parker
G-quadruplex - Wikipedia
WebMay 7, 2024 · Four-stranded G-quadruplexes (G4s) are DNA secondary structures in the human genome that are primarily found in active promoters associated with elevated … WebMar 3, 2024 · Abstract Guanine-rich nucleic acids can fold into G-quadruplex (G4) structures. Although endogenous RNAs contain sequences that can fold into RNA G4s (rG4s) in vitro, their folding and functions in vivo are not well understood. We show that the folding of putative rG4s in human cells into bona fide rG4 structures is dynamically … WebG‐quadruplexes are secondary structures of DNA that are found in the telomeric sequences. These structures are known to a play critical role in the development of cancer. This work … shanice peterson